578 Targeting PPARγ pathway and protecting skin microbiota balance for sebum harmonization in all skin types

Sebum is a well-recognised protection of the skin and minor changes on its composition quantity impact homeostasis. Over production induces microbiota dysbiosis in favor C. acnes proliferation leading to homeostasis dysbalance. Mangifera indica extract was traditionnaly used folk medicine for antibacterial antioxidant properties. In vitro studies demonstrated that main phytomarker identified, mangiferin, potent inhibitor agent lipogenesis. regulation evaluated sebocytes derived from iPS African, Asian Caucasian donors then by analyzing volume sebaceous glands explants. Genes expression analysis also performed sebocytes. Then molecular docking done between mangiferin PPARγ. The clinical were conducted 3 cohorts representative skins. Biometric analyses included measurement sebum level, quantification porphyrins. Skin New Generation Sequencing techniques. Inhibition lipase activity assessed vitro. lipogenesis evidenced reduced. Global genes revealed FDFT1, PPARG DGAT2 expressions down-regulated. Mangiferin interaction with confirmed docking. previous results reduction. showed an inhibition growth it through reduction porphyrin. proportions two major genera (Staphylococcus Acinetobacter) different placebo application whereas extract, maintained. M. proved global efficacy all types normalization PPAR pathway. conduct healthier better complexion.